Nano@Sens

Research

Research lines

Electrochemical sensors for the monitoring of emerging contaminants in water

Sensors are developed for the determination of organic pollutants present in tap and wastewater, particularly consisting of phytosanitary products and disinfection by-products. Sensors for these species exploit nanomaterials (metal nanoparticles and graphene) eventually associated with enzymes. Detection of PFAS exploits the use of molecular-printed polymers: biomimetic materials that selectively recognize the analyte for the presence of sites of specific dimension and shape.

Selected references:

Collaborations:

  • Prof. Claudia Crestini, Department of molecular sciences and nanosytems, Ca’ Foscari University of Venice, Italy
  • Prof. Matteo Gigli, Department of molecular sciences and nanosytems, Ca’ Foscari University of Venice, Italy 
  • Prof. Andrea Gambaro, Department of Environmental, Informatic and Statistical Sciences, Ca’ Foscari University of Venice, Italy
  • Dr. Manuela Melucci, Institute of Organic Synthesis and Photoreactivity, National Research Council, Italy

Sensors for the detection of biomarkers in biological fluids

The research group develops electrochemical sensors for the non-invasive analysis of various biomarkers in biological fluids, such as urine, saliva, and sweat. Multi-sensor platforms are developed for the determination of electrolytes and organic molecules in sweat and to define the effects of prolonged exposure to organic pollutants. The detection exploits innovative, environmentally sustainable, low-cost sensor platforms, obtained using polymers, paper, and fabric as substrates.

References:

  • Poletti, F., Scidà, A., Zanfrognini, B., Kovtun, A., Parkula, V., Favaretto, L., Melucci, M., Palermo, V., Treossi, E., Zanardi, C., Adv. Funct. Mater. 2022, 32, 2107941.
  • Fabrizio Poletti, Barbara Zanfrognini, Laura Favaretto, Vanesa Quintano, Jinhua Sun, Emanuele Treossi, Manuela Melucci, Vincenzo Palermo, Chiara Zanardi, Sens. Actuators B Chem, 344, 2021, 130253.

Collaborations:

Miniaturized sensors based on micro- and nano-electrodes for the analysis of complex matrices.

Electrode systems characterized by single arrays of micro- and nano-electrodes are developed to conduct “in situ” diagnostic investigations, and in small volume samples, on the electrochemical processes of electroactive species present in real complex matrices. The attention is mainly focused on applications in the environmental, clinical, and food fields for the determination of trace-level concentrations of natural components, metal contaminants, or biological indicators of the studied matrices.

Selected references:

Collaborations:

  • Prof. Paolo Oliveri, Department of Pharmacy, University of Genoa, Italy

Smart inks for electrochemical sensors

With the advent of flexible electronics, the old-fashioned and conventional solid-state technology will be replaced by conductive inks combined with low-cost printing techniques. 2D nanomaterials are ideal candidates to produce conductive inks, due to their excellent conductivity. The possibility to chemically modify these materials allows us to obtain inks responsive to external stimuli. Combined with classical printing techniques, such as screen and inkjet printing these inks can be used to produce electroanalytical platforms.

Selected references:

Collaborations:

Study and imaging of materials by using Scanning Electrochemical (SECM) and Microcapillary (SEMC) Microscopy

SECM and SEMC allow the performing of electrochemical investigations on the chemical reactivity of a variety of surfaces and interfaces (inorganic, organic, and biologic systems) at high spatial resolution. These techniques provide images of the chemical and redox properties of the investigated surfaces.

Selected references:

Active projects

SENSATI-ON-ALS
Development of a multi-functionalized microneedle biosensor as A novel device To Investigate ON a 3D skin model pyroptosis: a new biomarker for diagnosis and disease activity in Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized by the combined degeneration of upper and lower motor neurons. Despite intensive research efforts, no validated biomarkers for disease diagnosis and progression exist. The aim of SENSATI-ON-ALS is to develop biosensors for the detection of pyroptosis-related cytokines in skin interstitial fluid (ISF) that is considered an efficient source of inflammatory biomarkers that complements conventional sources, such as blood and urine. SENSATI-ON-ALS will open a new avenue for non-invasive measurement of pyroptosis-related biomarkers that could help clinicians for diagnosis and disease monitoring, and lastly will pave the way for new therapeutic strategies counteracting neurodegeneration by inhibiting inflammasome activation.

SENSATI-ON-ALS is developed by nano4Sens research group in collaboration with Dr, Ines Fasolino (CNR) and Dr. Raffaele Dubbioso (Università degli Studi di Napoli Federico II). 

PHOTOELECTROART
The photo-reactivity of artistic pigments: from the preservation of historical paintings to new opportunities as singlet oxygen generators

Madder lakes and geranium lakes are two pigments widely used in historic-artistic pieces. Under light exposure and in the presence of oxygen they generate singlet oxygen, one of the reactive oxygen species known for being a strong oxidant that promotes degradation reactions in historical paintings. This EU-funded project aims to provide further understanding regarding the generation of singlet oxygen from historical pigments, the impact of the (micro)environment, and how this can be applied to improve the preservation of historical paintings.
PHOTOELECTROART is based at Ca' Foscari's Department of Molecular Sciences and Nanosystems, under the supervision of Prof. Ligia Moretto and in collaboration with Prof. Karolien De Wael (University of Antwerp, Belgium) and Dr. Ferenc Borondics (Synchrotron Soleil, France).
 

Publications