Applied Mathematics

The laboratory focuses on the development and application of efficient numerical schemes for the approximation, learning, control, and uncertainty quantification of complex phenomena governed by partial differential equations.
The main focuses are on the modelling of phenomena in computational epidemiology, hydrology, and geosciences.
- Damiano Pasetto
- Gabriele Santin (Coordinator)
Contacts:
gabriele.santin@unive.it
Tel.: +39 041 234 8517
Collaborations
- Unità di Ricerca di Ca' Foscari dell'Istituto Nazionale di Alta Matematica (INdAM) [ITA]
- Augmented Intelligence Center, Fondazione Bruno Kessler (Italy)
- Gruppo UMI di Teoria dell’Approssimazione e Applicazioni (UMI-TAA) [ITA]
- UMI Group Socio-Epidemiological Modeling (MSE)
- Research ITalian network on Approximation (RITA)
- Cluster of Excellence for Simulation Science - SimTech, University of Stuttgart (Germany)
Publications
- Computational epidemiology
- Millevoi C.; Pasetto D.; Ferronato M. (2024) A Physics-Informed Neural Network approach for compartmental epidemiological models in PLOS COMPUTATIONAL BIOLOGY, vol. 20 (ISSN 1553-7358)
- Lemaitre J.C.; Pasetto D.; Zanon M.; Bertuzzo E.; Mari L.; Miccoli S.; Casagrandi R.; Gatto M.; Rinaldo A. (2022) Optimal control of the spatial allocation of COVID-19 vaccines: Italy as a case study in PLOS COMPUTATIONAL BIOLOGY, vol. 18 (ISSN 1553-7358)
- Mari L.; Casagrandi R.; Bertuzzo E.; Pasetto D.; Miccoli S.; Rinaldo A.; Gatto M. (2021) The epidemicity index of recurrent SARS-CoV-2 infections in NATURE COMMUNICATIONS, vol. 12, pp. 2752 (ISSN 2041-1723)
- Cencetti G.; Santin G.; Longa A.; Pigani E.; Barrat A.; Cattuto C.; Lehmann S.; Salathé M.; Lepri B. (2021) Digital proximity tracing on empirical contact networks for pandemic control in NATURE COMMUNICATIONS, vol. 12, pp. 1655 (ISSN 2041-1723)
- Bertuzzo E.; Mari L.; Pasetto D.; Miccoli S.; Casagrandi R.; Gatto M.; Rinaldo A. (2020) The geography of COVID-19 spread in Italy and implications for the relaxation of confinement measures in NATURE COMMUNICATIONS, vol. 11, pp. 4264 (ISSN 2041-1723)
- Surrogate modelling and model order reduction of partial differential equations
- Hammer M.; Wenzel T.; Santin G.; Meszaros-Beller L.; Little J.P.; Haasdonk B.; Schmitt S. (2025) A new method to design energy-conserving surrogate models for the coupled, nonlinear responses of intervertebral discs in BIOMECHANICS AND MODELING IN MECHANOBIOLOGY (ISSN 1617-7959)
- Alla, Alessandro; Oliveira, Hugo; Santin, Gabriele (2023) HJB-RBF Based Approach for the Control of PDEs in JOURNAL OF SCIENTIFIC COMPUTING, vol. 96 (ISSN 0885-7474)
- Haasdonk B.; Hamzi B.; Santin G.; Wittwar D. (2021) Kernel methods for center manifold approximation and a weak data-based version of the Center Manifold Theorem in PHYSICA D-NONLINEAR PHENOMENA, vol. 427, pp. 133007 (ISSN 0167-2789)
- Xia C.-A.; Pasetto D.; Hu B.X.; Putti M.; Guadagnini A. (2020) Integration of moment equations in a reduced-order modeling strategy for Monte Carlo simulations of groundwater flow in JOURNAL OF HYDROLOGY, vol. 590, pp. 125257 (ISSN 0022-1694)
- Koppel M.; Franzelin F.; Kroker I.; Oladyshkin S.; Santin G.; Wittwar D.; Barth A.; Haasdonk B.; Nowak W.; Pfluger D.; Rohde C. (2019) Comparison of data-driven uncertainty quantification methods for a carbon dioxide storage benchmark scenario in COMPUTATIONAL GEOSCIENCES, vol. 23, pp. 339-354 (ISSN 1420-0597)
- Koeppl T.; Santin G.; Haasdonk B.; Helmig R. (2018) Numerical modelling of a peripheral arterial stenosis using dimensionally reduced models and kernel methods in INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING, vol. 34 (ISSN 2040-7939)
- Efficient sampling and sparsity in kernel methods
- Santin, Gabriele; Wenzel, Tizian; Haasdonk, Bernard (2024) On the Optimality of Target-Data-Dependent Kernel Greedy Interpolation in Sobolev Reproducing Kernel Hilbert Spaces in SIAM JOURNAL ON NUMERICAL ANALYSIS, vol. 62, pp. 2249-2275 (ISSN 0036-1429)
- Wenzel, Tizian; Santin, Gabriele; Haasdonk, Bernard (2024) Stability of convergence rates: kernel interpolation on non-Lipschitz domains in IMA JOURNAL OF NUMERICAL ANALYSIS (ISSN 0272-4979)
- Cuomo S.; Erb W.; Santin G. (2023) Kernel-based models for influence maximization on graphs based on Gaussian process variance minimization in JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS, vol. 423, pp. 114951 (ISSN 0377-0427)
- Wenzel T.; Santin G.; Haasdonk B. (2021) A novel class of stabilized greedy kernel approximation algorithms: Convergence, stability and uniform point distribution in JOURNAL OF APPROXIMATION THEORY, vol. 262, pp. 105508 (ISSN 0021-9045)
For a complete list of publications, please visit the webpages of the members of the lab.
Research projects
Perturbation problems and asymptotics for elliptic differential equations
In this project we consider perturbation and asymptotic problems for elliptic differential equations. We consider several different types of perturbation: domain (regular and singular perturbation for electromagnetic, degenerate, Steklov, nonlinear and higher order problems, corner singularities, etc.), mass and geometry (eigenvalue bounds and optimization), coefficients (regularity and stability, constant/nonconstant cases). The main aim of the project is to exploit the interplay between potential theory and calculus of variations and, on a higher scale, to involve more prominently geometric ideas in unprecedented ways: we will not only study perturbation and asymptotic problems in Riemannian settings, but also apply geometric techniques for the study of problems in Euclidean spaces. Apart from actual perturbation problems, we also consider more abstract, foundational questions that are necessary to improve the understanding of the geometrical and functional structure, such as: the role of the mass from a geometric point of view; domain perturbation in a general Riemannian setting; reducible operators for solving general BVPs; numerical computation of potentials; regularity properties of layer potentials; etc.
HydroROM - Reduced order models of hydraulic protection systems for extreme water hazards
PI: Antonia Larese (UNIPD); project PRIN22 2022PXYYK5 (28/09/2023 - 27/09/2025)
Extreme hydrological events, such as floods and rock/debris or mud flows, are in rapid growth and this tendency will keep worsening in the near future. Our levees, dams, check dams, and flood control structures have mostly been conceived based on design criteria not adequate to the actual frequency and intensity of extreme hydrological events. This means that, in many cases, we cannot predict the response of an operating hydraulic structure to unforeseen events, preventing timely planning of adequate retrofitting intervention. The physical description of these hydraulic systems takes into account the mutual interaction between the fluid phase and the deformable boundary of the structures. The numerical simulation of these coupled systems is extremely computationally demanding, thus limiting the practical application of these numerical models. The goal of the project is the creation of Digital Twins (DTs) for hydraulic and protection structures under hydrological hazards such as floods and debris flows. The DT must be able to predict the structure response in real-time to adapt to the fast-flowing measurement data. The needed computational speed will be achieved combining Data Assimilation (DA) and Reduced Order Models (ROMs) to design machine learning techniques for complex and accurate high fidelity DTs. ROMs will capture the relevant features of the real process, while guaranteeing the computational efficiency for quasi real time applications. DAs will continuously correct and optimize the ROMs by the seamless flow of monitoring data during operational conditions.
Data-driven discovery and control of multi-scale interacting artificial agent systems
The main goal of the project consists in developing sustainable and flexible next-generation frameworks for data-driven modelling, optimization, and simulation of multi-scale interacting agent systems of utmost importance in industrial applications and socio-economic life. As a scientific aim, we investigate several approaches relying on learning-based mathematical methods to build and control physical data-driven models. The proposal is timely since learning-based methods have recently attracted the attention of the scientific community to fully exploit HPC hardware and the abundance of data, demanding new unifying concepts to address grand challenges.
Sito web: https://www.di.univr.it/?ent=progetto&id=5971&lang=en
EPIDOC - Epidemiological data assimilation and optimal control for short-term forecasting and emergency management of COVID-19 in Italy
PI: Damiano Pasetto; project FISR 2020, EPIDOC_FISR_2020IP_04249 (26/07/2021 - 26/01/2022)
The EPIDOC project will develop a reliable decision support system for short-term (1-3 weeks) prediction of the spatiotemporal spread of COVID-19 in Italy. The goal of the project is twofold: it will produce a platform that will automatically update the epidemiological forecast as soon as daily data become available (first phase) and evaluate the optimization of a portfolio of control actions to contain disease transmission (second phase). The model projections will be made directly accessible online on a dedicated platform. These goals will be achieved using a multidisciplinary approach that combines epidemiological modeling, dynamic systems analysis, numerical analysis, and optimization applied to estimation and control.
Last update: 25/03/2025